WebDec 26, 2024 · The point of departure (POD) for chronic dietary (all populations) exposures is thus the 5 mg/kg/day dose, based on changes in thyroid hormones (decreased T3, decreased T4, and increased TSH), and increased incidence of thyroid follicular cell hypertrophy in male and female rats at the next highest dose of 35/45 mg/kg/day (males … Web= 1) because the RfD was derived from a study using a chronic exposure protocol. An UF to extrapolate from a LOAEL to a NOAEL (UF. L) was not necessary (e.g., UF. L = 1) because the RfD was based on a NOAEL. Kociba et al. (1974) was a well-conducted, chronic drinking water study with an adequate number of animals. Histopathological …
The Risk Assessment Information System
WebJan 26, 2024 · An RfD is “an estimate of the concentration or dose of a substance . . . to which a human population ... The final chronic RfD for GenX chemicals is approximately 10 times lower than for PFOA or ... WebThe subchronic and chronic oral RfD values for Cr(VI) and Cr(III) are derived from no-observed-adverse-effect levels (NOAELs) of 1.47 g/kg Cr(III)/day and 25 ppm of potassium dichromate (Cr[VI]) in drinking water, respectively (Ivankovic and Preussmann, 1975; MacKenzie et al., 1958). The inhalation RfC values for both Cr(III) and Cr(VI) are ... pheonix fall out boys osu
EPA Released Draft Toxicological Review of PFHxA - The National Law Review
WebFeb 3, 2024 · The draft toxicity assessment for PFHxA concludes that the evidence supports a reference dose of 5×10^-4 milligrams per kilogram bodyweight per day (mg/kg-day), which represents the most that an... Webfor acute (one-day), chronic (non-cancer), and carcinogenic effects (10-6 -10-4 . risk level) to protect against adverse health effects from exposure to pesticides that may be found in surface or ground water used for drinking. The HHBP table lists the acute as well as chronic RfD, the noncancer benchmarks for WebSubchronic/Chronic RfD. No neurological changes, based on functional observation battery and locomotor activity evaluations, were reported in adult rats following 90 days of … pheonixes itchio