WebMar 28, 2024 · Articles ASAP (as soon as publishable) are posted online and available to view immediately after technical editing, formatting for publication, and author proofing. Web进一步地,所述creka修饰的脂质体至少包括卵磷脂、胆固醇、creka-peg2000-dspe;且卵磷脂、胆固醇、creka-peg2000-dspe的摩尔比为2:1:0.05-0.77。 进一步地,所述CREKA-PEG2000-DSPE中的聚乙二醇的分子量为200。
DOPE-PEG-NH2,二油酰磷脂酰乙醇胺-聚乙二醇-胺
WebFeb 1, 2024 · In our work, CREKA was conjugated to DMPE-PEG-Mal through the reaction between the thiol group of CREKA and the Mal group. The chemical structure and 1 H NMR spectrum of the resulting DMPE-PEG-CREKA were shown in Fig. 1.D 2 O signals at 4.65 ppm acted as a reference to determine chemical shifts. The disappearance of the peak at … Web本项目拟采用脂质体融合技术和脂质流动效应,将更加稳定的右旋肽d-creka修饰在干细胞表面;在体外评价d-creka修饰干细胞的稳定性、fb靶向性和安全性的基础上,将其经血管 … aldi generator ferrex
Synthesis and characterization of CREKA-targeted polymers for …
WebPoon等 [48] 用具有氧化铁和氧化锰核心的纳米颗粒结合组装纤维蛋白靶向肽CREKA,在体外实验中发现于血凝块的结合效率是非靶向纳米颗粒的3~5倍,MRI信号2倍增强,可特异度检测动脉粥样硬化发病过程中的血栓形成。 Web凝血酶(英语: Thrombin ,EC 3.4.21.5)是一种“胰蛋白酶样”丝氨酸蛋白酶蛋白质,在人体中被F2基因所编码 。 在凝血作用第一级级联反应中,凝血酶原(凝血因子Ⅱ)被蛋白水解性切除以生成凝血酶,级联反应最终阻止了血液的继续流失。凝血酶转而作为一种丝氨酸蛋白酶以使可溶性的纤维蛋白原 ... Web摘要:. 目的构建以CREKA肽修饰的包载多西他赛脂质体 (CREKA-lipo-DTX),评价该药物传递系统体外靶向性和体外抗肿瘤效应.方法首先采用迈克尔加成反应合成靶向部分DSPE-PEG2000-CREKA,随后使用薄膜水化-超声法制备CREKA-lipo-DTX并对其基本表征进行评价;将PC-3细胞和RWPE-1 ... aldi generateur