WebMay 2, 2006 · The CTGF siRNA treatment markedly reduced serum procollagen type III, hepatic hydroxyproline and liver fibrosis staging. Conclusions. Silencing CTGF expression with siRNA demonstrates therapeutic potential to prevent liver fibrosis by inhibiting HSC activation with consequent extracellular matrix accumulation and the upregulation of TGF … WebConnective tissue growth factor (CTGF) plays a critical role in the hepatic stellate cells (HSCs)-mediated development of hepatic fibrosis. Nevertheless, the effects of CTGF …
Hepatic stellate cells as key target in liver fibrosis - PMC
WebNov 5, 2024 · Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and even cancer. ... CTGF, p16, CCL2 and SA-β-gal, ultimately leading to a profibrogenic micro-environment, HSC activation, and enhanced liver fibrosis ... WebDec 12, 2024 · TGF-β1, platelet-derived growth factor (PDGF), connective tissue growth factor (CTGF), TNF-α, and vascular endothelial growth factor (VEGF) are all involved in key mechanisms of fibrosis. 9,14 TGF-αis particularly important in mediating stellate cell activation to myofibroblasts and stellate cell collagen production. 14 VEGF and PDGF … frick\u0027s turkey legs
Cells Free Full-Text The Role of CTGF in Liver Fibrosis Induced …
WebMay 28, 2024 · CTGF is a primary mediator of TGF-β-induced pulmonary fibrosis. CTGF was found to be overexpressed in fibrotic lesions in major organs, including the lung, kidney, liver, skin, cardiovascular system, gastrointestinal system, eye, and gingiva [8]. WebAug 22, 2024 · Accordingly, hepatic fibrosis occurs when liver is repeatedly and continuously injured. Damage to hepatocytes triggers the release of reactive oxygen species (ROS) and inflammatory mediators, which would stimulate carcinogenic process . Untreated fibrosis may progress to liver cirrhosis, leading to organ failure and hepatoma [3,4]. … WebJun 1, 2009 · CTGF participates in cell proliferation, migration, and differentiation and mediates profibrotic activity by acting either directly, or as a co-factor for TGF beta 1, … father spyridon wikipedia