WebThe cells became weakly adherent, developed conspicuous cytoplasmic blebs, and displayed mature megakaryocytic characteristics by light microscopy such as the development of azurophilic cytoplasmic granules and a mosaic pattern of oxyphilic patches, multiplication of nuclei, and enhancement of the PAS reaction and alpha-naphthyl acetate ... WebBlebs are membrane ‘bubbles’ that emerge in the cellular periphery. Blebs form when the actomyosin cortex that underlies the plasma membrane separates from the phospholipid …

Cytoplasmic Blebs in T-Cell Prolymphocytic Leukemia

WebCytoplasmic expression of TCL1 is another notable finding in T-PLL cells. Importantly, alterations in chromosome 14 and TCL1 are seen in more than 90 percent of patients. … WebThe nucleus is three to five times the size of the cytoplasm, and is generally round or oval in shape. Several nucleoli are visible, while the chromatin varies from cell to cell, ranging … core values in good work ethics

An inside-out origin for the eukaryotic cell - BMC Biology

WebCytoplasmic fluidity in the bleb is much higher in the expansion phase than in the retraction phase. Moreover, a number of molecules including the actin polymerization promoting protein Mena are specifically concentrated in the cytoplasm of expanding blebs. WebThe cytoplasmic membrane may show irregular contours, and some examples show membrane protrusions or blebs. A spectrum of morphologies toward … WebHyperbasophilic Variant of Acute Promyelocytic Leukemia - 1. Cells in this morphologic variant of APL have few granules. Instead, they are deeply basophilic with cytoplasmic blebs, making them reminiscent of micromegakaryocytes. fancy genre