Dalatazide
WebApr 11, 2024 · Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. Several of its analogs are some of the most potent and selective blockers of this channel. … WebNov 9, 2016 · Dalazatide (formerly known as ShK-186) is a first-in-class investigational drug designed to selectively target cells that cause autoimmune diseases such as lupus …
Dalatazide
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WebVeledimex （INXN-1001） 是昆虫蜕皮激素蜕皮激素的合成类似物，是一种具有口服活性的用于专有的基因治疗启动子系统的激活配体。 WebThis product is used to treat high blood pressure (hypertension), heart failure, or extra fluid in the body ().Lowering high blood pressure helps prevent strokes, heart attacks, and …
WebSelectivity of dalatazide (ShK-186), a synthetic derivate of the sea anemone toxin ShK, was achieved by chemical modification and has successfully reached clinical trials as a … WebDec 17, 2024 · Europe PMC is an archive of life sciences journal literature.
WebMay 1, 2024 · Selectivity of dalatazide (ShK-186), a synthetic derivate of the sea anemone toxin ShK, was achieved by chemical modification and has successfully reached clinical trials as a potential therapeutic for treating autoimmune diseases. Other peptides and small-molecule inhibitors are critically evaluated for their lead-like characteristics and ... WebMay 3, 2024 · The K 1.3 voltage-gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting K 1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, …
WebSelectivity of dalatazide (ShK-186), a synthetic derivate of the sea anemone toxin ShK, was achieved by chemical modification and has successfully reached clinical trials as a potential therapeutic for treating autoimmune diseases. Other peptides and small-molecule inhibitors are critically evaluated for their lead-like characteristics and ...
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