Hand2
WebOct 26, 2016 · Given the substantial number of uncharacterized promoter-associated long non-coding RNAs encoded by the mammalian genome 9, the Uph – Hand2 regulatory … Heart- and neural crest derivatives-expressed protein 2 is a protein that in humans is encoded by the HAND2 gene. The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins Hand1 … See more HAND2 has been shown to interact with GATA4, NKX2.5, PPP2R5D, PHOX2A., TWIST1, and TWIST2. See more Hand2 interactions with TWIST1 and TWIST2 genes are critical for proper limb development. Recent literature shows over dosage of Hand2 … See more • Srivastava D (1999). "HAND proteins: molecular mediators of cardiac development and congenital heart disease". Trends in Cardiovascular Medicine. 9 (1–2): … See more HAND2 is an important transcription factor in development of the endothelial to mesenchymal transition (EMT) which allows for the development of the cardiac cushion in the … See more • HAND2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article … See more
Hand2
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WebJan 12, 2024 · HAND2 knockdown increased ER-α expression and alleviated the antitumor effect of ART in vitro and in vivo. Overall, our study first showed that ART could be an effective antitumor agent through modulating ER-α-mediated LKB1/AMPK/mTOR pathway in the HAND2 dependent manner. WebMar 30, 2024 · Functionally, hand2 loss disrupts mesothelium formation with reduced progenitor cells and perturbed migration. In mouse and human mesothelioma, we …
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WebSee all HAND2 primary antibodies Description Rabbit monoclonal [EPR19451] to HAND2 Host species Rabbit Tested applications Suitable for: IHC-P, WB, ICC/IF, IP, Flow Cyt … WebMay 20, 2024 · HAND2 cooperates with MYCN to compete with nucleosomes and regulate global gene transcription. The treatment of NB with an Aurora A kinase inhibitor plus HDAC inhibitor potently downregulates both MYCN and the CRC TFs and suppresses MYCN -amplified NB tumor growth. Our study identifies a “ cooperative collaboration ” among …
WebJul 4, 2024 · Removal of Hand2 from these areas disrupted cell adhesion, including adherens junction and cell-matrix adhesions. Mechanistically, HAND2 regulates the expression of the actin and myosin cytoskeleton together with their regulators to establish cell adhesions for epithelial formation in the TZ, facilitating OFT morphogenesis. ...
WebOur passion. The complete source for packaging services. H2H is a cutting-edge, full-service contract packager who produces, labels and ships high-quality products from our … linthicum precisionWebThe Hand2 proteins are evolutionarily more conserved, and human and mouse Hand2 have a completely identical amino acid sequence. Expression of the mouse Hand2 gene is first observed in maternally derived deciduum at embryonic day 7.5 (E7.5). Its expression in mouse embryos subsequently starts at E7.75 in the lateral mesoderm, which migrates ... linthicum plumbing reviewsWebFeb 1, 2024 · The analysis of HAND2-AS1 expression in GC tissues and normal tissues was performed at StarBase. The results presented in Fig. 1 A revealed that HAND2-AS1 expression was decreased in GC tissues compared with normal tissues. Moreover, RT-qPCR revealed that HAND2-AS1 expression level in GC cells was lower than that in … house cottage styleWebFeb 18, 2011 · Our results identified Hand2, a critical regulator of morphogenesis in a variety of tissues ( 8, 9 ), as a potential PR-regulated gene. Real-time polymerase chain reaction (PCR) confirmed that the expression of Hand2 mRNA was greatly reduced in the uteri of RU-486–treated mice ( 10) (fig. S1A). linthicum plumbersWebFeb 24, 2011 · Hand2 expression is robust throughout the endocardium, SHF and OFT. Interestingly, Hand2 expression is not detected within the ventricular myocardium at E8.5 and, in whole-mount view, the Hand2 endocardial expression is visible through the thin myocardial wall (Figure 2F, red arrow). linthicum post office hoursWebMay 10, 2004 · Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and … linthicum plumbing and drain cleaning incWebJan 6, 2024 · HAND2 has a conserved N-terminal polyalanine tract and several potential phosphorylation sites. It shares 100% amino acid identity with a partial rat Hand2 protein. HAND2 also shares 92% and 97% identity with chicken and mouse Hand2, with 100% amino acid identity within the bHLH region. linthicum plumbing drain cleaning