WebThese findings reveal how specific IDPs can phase separate to form permeable, lowdensity (semi-dilute) liquids, whose structural features are likely to strongly impact biological function. AB - Many intracellular membraneless organelles form via phase separation of intrinsically disordered proteins (IDPs) or regions (IDRs). Web11 feb. 2024 · Bioinformatician PostDoc. VIB. Dec 2024 - Oct 20241 year 11 months. Brussels, Brussels Region, Belgium. VIB-VUB Center for Structural Biology, Group for Intrinsically Disordered Proteins. Projects: - Studying the biology of phase separation driver proteins in silico. - MD simulations and docking on proteins and protein complexes.
Erdős Gábor - Bioinformatic scientist - MTA-ELTE Biokémiai intézet ...
Web3 sep. 2024 · Phase separation of FUS-CHOP is not dependent on a central core region within the FUS PrLD. (A) Schematic of FUS-CHOP–eGFP type I internal truncations. (B) NIH 3T3 cells transfected with full-length (FL) or truncated (Δ50–75, Δ75–125, Δ50–125 or ΔDBD) FUS-CHOP–eGFP type I constructs. WebPharmacokinetics and tolerability of IDP-73152 mesylate after a single oral administration under ... Chromatographic separation was performed on a C18 column (50 mm × 2.1 mm, 3 μm) at 40°C with a 0.2 mL/min flow rate and 5 μL ... In a previous phase I study, the absorption rate of IDP-73512 was similar, but the half-life was ... saks off 5th charlotte
Interplay of folded domains and the disordered low-complexity domain …
Web26 sep. 2016 · Some IDPs undergo liquid-liquid phase separation in the aqueous milieu of the living cell. The resulting phase with enhanced IDP concentration can function as a major component of membraneless organelles that, by creating their own IDP-rich microenvironments, stimulate critical biological functions. Web24 jun. 2024 · Upon stress challenges, proteins/RNAs undergo liquid–liquid phase separation (LLPS) to fine-tune cell physiology and metabolism to help cells adapt to adverse environments. The formation of LLPS has been recently linked with intracellular pH, and maintaining proper intracellular pH homeostasis is known to be essential for the … WebLOGICAL DATA SepARATION Rubrik built Rubrik Security Cloud with logical data separation as a core feature and capability. Rubrik logically separates customer data within Rubrik Security Cloud’s internal infrastructure to ensure that each customer only has access to their own account and information. DATA DURABILITY things old men do