WebMay 17, 2024 · PSMA is a largely prostate-specific transmembrane protein expressed 100- to 1,000-fold higher in prostatic adenocarcinoma than in the benign prostate. 1 Of importance, PSMA expression is increased on androgen deprivation and is highest in high-grade and castration-resistant prostate cancer (CRPC). 2,3 Small molecules, antibodies, … WebDec 10, 2024 · Special Issue Information. This Special Issue is about Prostate-Specific Membrane Antigen (PSMA), which has been the subject of a huge number of studies during the last 25 years. PSMA is a transmembrane protein, highly expressed by prostate epithelial cells and strongly upregulated in prostate cancer. PSMA expression levels are directly ...
Prostate Cancer - INTRODUCTION - Uroweb
WebPSMA. Voor een PET-CT-scan wordt een licht-radioactieve stof gebruikt. Bij prostaatkanker is er een speciale radioactieve stof: PSMA. PSMA hecht zich met name aan de kwaadaardige cellen van de prostaat. Radioactieve stof is niet gevaarlijk. Na het onderzoek verdwijnt de radioactieve stof voor het grootste deel uit je lichaam. WebMar 18, 2024 · The phase 3 VISION trial is investigating 177 Lu-PSMA-617 in men with metastatic castrate-resistant prostate cancer who had failed both a novel hormone therapy, such as abiraterone (Zytiga) or enzalutamide (Xtandi), and a taxane-based chemotherapy (NCT03511664). VISION used a diagnostic PSMA PET scan to select patients for the … ho railroad scenery
Novel Role of Prostate-Specific Membrane Antigen in …
WebConsequently, PSMA-based imaging technologies for the detection of metastatic disease in advanced-stage prostate cancer patients were developed and PSMA-based radioligand therapy was introduced as a therapeutic regimen in metastasized prostate cancer[3–10]. In addition, PSMA is expressed in the endothelium of tumor-associated neovasculature of WebThough negligible at first sight, the heterogeneity in pharmacokinetic features privileges 18F-PSMA-1007 over 68Ga-PSMA-11, e.g., increased renal elimination of 68Ga-PSMA-11 over 18F-PSMA-1007, could lead to false negative results because a vital lesion of the prostate or prostatic bed could be masked by the presence of urine and so tracer accumulation in … WebJan 1, 2016 · Request PDF PSMA-PET Voor prostaatkanker en eventuele Metastasen (68)Gallium (Ga)PSMA PET/CT (PSMA stands for "prostatespecific membrane antigen") … look up movies on youtube