WebIsabel is trained as a clinical microbiologist. Since 2003 she has been working as an investigator at the Center for Vaccinology (CEVAC), Ghent University Hospital (UZ Gent). Since October 2024 she is the principal investigator of CEVAC (UZ Gent/UGent). Isabel is also the coordinating physician of the infection control team at UZ Gent.

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